Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. uri icon

Overview

abstract

  • BACKGROUND: Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue. METHODS: Ovarian tissue was cryopreserved from a 30-year-old woman with breast cancer before chemotherapy-induced menopause, and this tissue was transplanted beneath the skin of her abdomen 6 years later. FINDINGS: Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and oestrogen production. The patient underwent eight oocyte retrievals percutaneously and 20 oocytes were retrieved. Of the eight oocytes suitable for in-vitro fertilisation, one fertilised normally and developed into a four-cell embryo. INTERPRETATION: Fertility and ovarian endocrine function can be preserved in women by long-term ovarian tissue banking.

publication date

  • March 13, 2004

Research

keywords

  • Cryopreservation
  • Embryonic and Fetal Development
  • Ovary
  • Transplantation, Heterotopic

Identity

Scopus Document Identifier

  • 1642369930

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(04)15728-0

PubMed ID

  • 15031026

Additional Document Info

volume

  • 363

issue

  • 9412