Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients. Academic Article uri icon

Overview

abstract

  • A new Brodmann area (BA) delineation approach was applied to FDG-PET scans of autistic patients and healthy volunteers (n = 17 in each group) to examine relative glucose metabolism (rGMR) during performance of a verbal memory task. In the frontal lobe, patients had lower rGMR in medial/cingulate regions (BA 32, 24, 25) but not in lateral regions (BA 8-10) compared with healthy controls. Patients had higher rGMR in occipital (BA 19) and parietal regions (BA 39) compared with controls, but there were no group differences in temporal lobe regions. Among controls, better recall and use of the semantic-clustering strategy was associated with greater lateral and medial frontal rGMR, while decreased rGMR in medial-frontal regions was associated with greater perseverative/intrusion errors. Patients failed to show these patterns. Autism patients have dysfunction in some but not all of the key brain regions subserving verbal memory performance, and other regions may be recruited for task performance.

publication date

  • January 1, 2004

Research

keywords

  • Autistic Disorder
  • Blood Glucose
  • Cerebral Cortex

Identity

Scopus Document Identifier

  • 1842559375

Digital Object Identifier (DOI)

  • 10.1159/000076719

PubMed ID

  • 15034226

Additional Document Info

volume

  • 49

issue

  • 3