Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Review uri icon

Overview

abstract

  • OBJECTIVE: The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans. STUDY DESIGN: We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated. RESULTS: One hundred seventy-three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed. CONCLUSIONS: Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.

publication date

  • March 1, 2004

Research

keywords

  • Anti-Bacterial Agents
  • Ear, Middle

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.otohns.2003.12.008

PubMed ID

  • 15054364

Additional Document Info

volume

  • 130

issue

  • 3 Suppl