The ABCs of artificial antigen presentation. Review uri icon

Overview

abstract

  • Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell-mediated immunity.

publication date

  • April 1, 2004

Research

keywords

  • Antigen Presentation
  • Antigens
  • Immunotherapy

Identity

Scopus Document Identifier

  • 1842582044

Digital Object Identifier (DOI)

  • 10.1038/nbt955

PubMed ID

  • 15060556

Additional Document Info

volume

  • 22

issue

  • 4