Gender and lung cancer. Review uri icon

Overview

abstract

  • Accumulating data suggest that the risks for development of lung cancer are different in women compared with men. An increased susceptibility in women to the adverse effects of tobacco may be due to higher levels of DNA adducts, decreased DNA repair capacity, increased frequency of mutations in tumor suppressor genes, and hormonal differences. There are many sex and gender differences in lung cancer presentation, including a greater proportion of adenocarcinoma among women, a greater representation of women in cohorts of younger patients who have lung cancer, and women who do not smoke are more likely to be diagnosed with lung cancer than men. When guidelines for screening, preventive therapies, and treatment options for lung cancer are outlined these differences should be considered.

publication date

  • June 1, 2004

Research

keywords

  • Lung Neoplasms

Identity

Scopus Document Identifier

  • 1942476116

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2004.01.006

PubMed ID

  • 15099898

Additional Document Info

volume

  • 25

issue

  • 2