Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Academic Article uri icon

Overview

abstract

  • Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.

publication date

  • June 8, 2004

Research

keywords

  • Carcinoma, Papillary
  • Neoplasms, Radiation-Induced
  • Point Mutation
  • Proto-Oncogene Proteins c-raf
  • Thyroid Neoplasms

Identity

Scopus Document Identifier

  • 2442642971

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2003.12.004

PubMed ID

  • 15145515

Additional Document Info

volume

  • 209

issue

  • 1