The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications. Review uri icon

Overview

abstract

  • Preclinical proof-of-concept, feasibility and efficacy studies in lower animals resulted in the accumulation of data that served as a backbone for clinical trials with the recombinant, osteogenic bone morphogenetic protein-2 (BMP-2). Among the important observations was the dependence of dose and carrier on the outcome for osseous union in relation to the animal model used. Clinical outcome data for spinal applications indicate better overall results compared with traditional controls that utilised autogenous iliac crest bone graft for fusion. Parameters include less blood loss, less operating room time and costs, better fusion outcomes and increased patient satisfaction. At this juncture, the long journey from the identification of BMP-2 in demineralised bone fraction to FDA approval for use in a singular orthopaedic application has been completed. It has been demonstrated to be safe, efficacious and cost-effective, leading to increased patient satisfaction and improved clinical outcome.

publication date

  • May 1, 2004

Research

keywords

  • Bone Development
  • Bone Morphogenetic Proteins
  • Orthopedic Procedures
  • Transforming Growth Factor beta

Identity

Scopus Document Identifier

  • 2442638878

Digital Object Identifier (DOI)

  • 10.1517/14712598.4.5.741

PubMed ID

  • 15155165

Additional Document Info

volume

  • 4

issue

  • 5