Role of reporter gene imaging in molecular and cellular biology. Review uri icon

Overview

abstract

  • Molecular imaging, including reporter gene methods, provides a unique opportunity to study biology in a living subject, thereby allowing physiological events to be monitored in an intact microenvironment. This review takes a molecular and cell biology perspective on recent studies which utilize reporter gene imaging as a tool to non-invasively monitor specific molecular biology pathways in vivo. Studies in rodent models demonstrate the feasibility of reporter gene imaging to visualize and measure key cellular pathways, such as transcription, translation and protein-protein interactions. The review indicates that molecular imaging is likely to be useful in the translation of molecular biology to medicine and biotechnological applications.

publication date

  • May 1, 2004

Research

keywords

  • Genes, Reporter
  • Optics and Photonics

Identity

Scopus Document Identifier

  • 2942741151

Digital Object Identifier (DOI)

  • 10.1515/BC.2004.039

PubMed ID

  • 15195994

Additional Document Info

volume

  • 385

issue

  • 5