The ultrastructure of transplanted rabbit retinal epithelium. Academic Article uri icon

Overview

abstract

  • Retinal epithelial cells from pigmented rabbits have been cultured and radiolabelled during division with 3H-thymidine and transplanted to the subretinal space of albino rabbits using a pars plana transvitreal approach. The host rabbits were maintained on cyclosporine immunosuppression after transplantation surgery. The transplant cells survive and maintain a morphologically normal appearance for at least 5 months. The pigmented epithelial cells retain their pigmentation and become integrated with the host retinal epithelium forming junctional complexes with both the host and other transplant cells. The transplant cells contact host photoreceptors with their apical processes and phagocytize outer segments. There appears to be no significant cell division among the transplant cells.

publication date

  • January 1, 1992

Research

keywords

  • Pigment Epithelium of Eye

Identity

Scopus Document Identifier

  • 0026764437

Digital Object Identifier (DOI)

  • 10.1007/BF00175936

PubMed ID

  • 1521816

Additional Document Info

volume

  • 230

issue

  • 5