p27 and Barrett's esophagus: a review*. Review uri icon

Overview

abstract

  • The rising prevalence of Barrett's esophagus and Barrett's associated adenocarcinoma in the Western world has stimulated increasing interest in this disease. This has resulted in a plethora of articles concerning its molecular biology, but the tumor suppressor gene, p27, has received little attention. In this article, we review the literature concerning the role of p27 in Barrett's esophagus and its malignant transformation, and we evaluate its possible role as an important clinical biomarker, as well as potential chemopreventive clinical agents aimed at substituting its antitumoral activity.

publication date

  • January 1, 2004

Research

keywords

  • Adenocarcinoma
  • Barrett Esophagus
  • Cell Cycle Proteins
  • Esophageal Neoplasms
  • Genes, Tumor Suppressor
  • Tumor Suppressor Proteins

Identity

Scopus Document Identifier

  • 4043087780

Digital Object Identifier (DOI)

  • 10.1111/j.1442-2050.2004.00402.x

PubMed ID

  • 15230722

Additional Document Info

volume

  • 17

issue

  • 2