The role of 5-alpha-reductase inhibition as monotherapy in view of the MTOPS data. Review uri icon

Overview

abstract

  • Medical treatment for the symptoms of benign prostatic hyperplasia (BPH) consists of a blockers and 5-alpha-reductase inhibitors. Data suggest that 5-alpha-reductase inhibitors can prevent progression of BPH and reduce the risk of BPH-related surgery, especially in men with large-volume prostates. Results from the largest randomized, prospective, placebo-controlled trial, the Medical Therapy of Prostatic Symptoms trial, have been presented. These results support the notion of using 5-alpha-reductase inhibitors for the prevention of BPH progression and BPH-related surgery. Furthermore, long-term 5-alpha-reductase inhibitor monotherapy, although slow in onset, is a viable therapy for symptom relief in men with mild to moderate symptoms.

publication date

  • August 1, 2004

Research

keywords

  • 5-alpha Reductase Inhibitors
  • Enzyme Inhibitors
  • Finasteride
  • Prostatic Hyperplasia

Identity

Scopus Document Identifier

  • 14744299536

Digital Object Identifier (DOI)

  • 10.1007/s11934-004-0050-6

PubMed ID

  • 15260927

Additional Document Info

volume

  • 5

issue

  • 4