Nicotine-mediated plasticity in robust nucleus of the archistriatum of the adult zebra finch. Academic Article uri icon

Overview

abstract

  • Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a valuable model to study synaptic plasticity and its implications to behavioral learning. Electrophysiological recordings in the robust nucleus of the archistriatum (RA) in adult zebra finch brain slices reveal that tetanic stimulation alone does not produce LTP. However, LTP is induced by such stimulation in the presence of nicotine. The nicotine-mediated LTP is blocked by dihydro-beta-erythroidine (DHbetaE, 1 microM), an antagonist having a greater effect against nAChRs containing the alpha 4 subunit. In the presence of methyllcaconitine (MLA, 10 nM), an antagonist of nAChRs containing the alpha 7 subunit, a long-term depression (LTD) is unmasked, implicating a bi-directional type of plasticity in the zebra finch RA, which is modulated by differential activation of nAChR subtypes. Intracellular recordings from single neurons show a depression of the afterhyperpolarization (AHP) and an increase in frequency of evoked and spontaneous action potentials in the presence of nicotine. These results suggest that nicotinic cholinergic mechanisms may play a critical role in synaptic plasticity in the zebra finch song system and thereby influence song learning and plasticity.

publication date

  • August 20, 2004

Research

keywords

  • Corpus Striatum
  • Neural Pathways
  • Neuronal Plasticity
  • Presynaptic Terminals
  • Receptors, Nicotinic
  • Songbirds

Identity

Scopus Document Identifier

  • 3242721426

Digital Object Identifier (DOI)

  • 10.1016/j.brainres.2004.05.051

PubMed ID

  • 15262210

Additional Document Info

volume

  • 1018

issue

  • 1