Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy. Academic Article uri icon

Overview

abstract

  • Prodrugs of potent aldehyde analogues of the anticancer drug doxorubicin (Dox) were synthesized. These prodrugs were efficiently activated by antibody 93F3 and no drug formation was observed in the absence of 93F3 in either phosphate buffered saline or cell culture media. In the presence of antibody 93F3, these prodrugs were activated and decreased the proliferation of human cancer cells in in vitro proliferation assays.

authors

  • Sinha, Subhash
  • Li, Lian-Sheng
  • Watanabe, Shin-Ichi
  • Kaltgrad, Eiton
  • Tanaka, Fujie
  • Rader, Christoph
  • Lerner, Richard A
  • Barbas, Carlos F

publication date

  • October 25, 2004

Research

keywords

  • Aldehydes
  • Antibodies, Catalytic
  • Prodrugs

Identity

Scopus Document Identifier

  • 8344238182

Digital Object Identifier (DOI)

  • 10.1002/chem.200400419

PubMed ID

  • 15378729

Additional Document Info

volume

  • 10

issue

  • 21