The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus. Academic Article uri icon

Overview

abstract

  • The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.

publication date

  • January 1, 1979

Research

keywords

  • B-Lymphocytes
  • Lupus Erythematosus, Systemic

Identity

PubMed Central ID

  • PMC371930

Scopus Document Identifier

  • 0018380803

Digital Object Identifier (DOI)

  • 10.1172/JCI109270

PubMed ID

  • 153913

Additional Document Info

volume

  • 63

issue

  • 1