Resting [Ca2+]i and [Ca2+]i transients are similar in fibroblasts from normal and Alzheimer's donors. Academic Article uri icon

Overview

abstract

  • Previous studies have reported that resting concentrations of intracellular calcium ion were markedly reduced in cultured dermal fibroblasts from Alzheimer's disease patients and that the ability of these cells to respond to serum stimulation was also decreased as compared to both young and age-matched control cells. In this study we have carefully reexamined these parameters in several of the same lines of fibroblasts and fail to find major differences in resting cytosolic calcium [Ca2+]i, in the response of [Ca2+]i to serum stimulation or in cell spreading in the AD cells as compared to young controls. The present findings suggest that cytoplasmic ionic calcium levels are neither pathognomonic for Alzheimer's cells nor of diagnostic value.

publication date

  • January 1, 1992

Research

keywords

  • Alzheimer Disease
  • Calcium
  • Fibroblasts

Identity

Scopus Document Identifier

  • 0026611851

Digital Object Identifier (DOI)

  • 10.1016/0197-4580(92)90005-i

PubMed ID

  • 1542378

Additional Document Info

volume

  • 13

issue

  • 1