Quinolone-resistant Haemophilus influenzae: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin. Academic Article uri icon

Overview

abstract

  • Stepwise selection of ciprofloxacin-resistant Haemophilus influenzae mutants produced first-, second-, third-, and fourth-step substitutions in GyrA (S84Y), ParC (S84R), GyrA (D88N), and ParC (E88K), respectively. Successive mutations raised the mutant selection window. The wild-type selection window for garenoxacin, levofloxacin, and moxifloxacin was also measured.

publication date

  • November 1, 2004

Research

keywords

  • Anti-Bacterial Agents
  • Haemophilus influenzae
  • Mutation
  • Quinolines

Identity

PubMed Central ID

  • PMC525419

Scopus Document Identifier

  • 7244251626

Digital Object Identifier (DOI)

  • 10.1128/AAC.48.11.4460-4462.2004

PubMed ID

  • 15504883

Additional Document Info

volume

  • 48

issue

  • 11