Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients. Academic Article uri icon

Overview

abstract

  • Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis and was shown to be effective in the prevention of catheter-related bloodstream infections (CR-BSI). In this pilot study, we used taurolidine solution as an intravenous (i.v.) lock into the totally implantable intravascular devices of 11 consecutive oncological patients with catheter-related bloodstream infections not responding to systemic antimicrobial chemotherapy. All patients recovered completely from the infection. No adverse drug effects were seen. Three patients were successfully retreated for a recurrent infection. Our data suggest a beneficial role of taurolidine i.v. lock for the therapy of catheter-related bloodstream infections in oncological patients. Taurolidine i.v. lock application is feasible and could especially be useful in infections resistant to antibiotic chemotherapy.

publication date

  • November 1, 2004

Research

keywords

  • Anti-Infective Agents
  • Bacteremia
  • Catheterization, Central Venous
  • Prosthesis-Related Infections
  • Taurine
  • Thiadiazines

Identity

Scopus Document Identifier

  • 7044235802

Digital Object Identifier (DOI)

  • 10.1016/j.ijantimicag.2004.06.006

PubMed ID

  • 15519483

Additional Document Info

volume

  • 24

issue

  • 5