Select forms of tumor cell apoptosis induce dendritic cell maturation. Academic Article uri icon

Overview

abstract

  • Dendritic cells (DC) play a crucial role in initiating immune responses to tumors. DC can efficiently present antigens from apoptotic tumor cells, but apoptotic cells are thought to lack the inflammatory signals required to induce DC maturation. Here, we show that apoptosis of 67NR mouse carcinoma cells via the Fas (CD95) pathway or induced by the anticancer drug bortezomib (PS-341) but not by ultraviolet irradiation is associated with the production of maturation signals for DC. These data have important implications for the effects of chemotherapy on antitumor immunity in solid and hematologic malignancies.

publication date

  • November 29, 2004

Research

keywords

  • Apoptosis
  • Dendritic Cells
  • Mammary Neoplasms, Experimental
  • Tamoxifen

Identity

Scopus Document Identifier

  • 14244262560

Digital Object Identifier (DOI)

  • 10.1189/jlb.0804478

PubMed ID

  • 15569694

Additional Document Info

volume

  • 77

issue

  • 3