Diagnosis and treatment of primary central nervous system lymphoma. Review uri icon

Overview

abstract

  • Primary central nervous system lymphoma (PCNSL) is an uncommon form of non-Hodgkin's lymphoma (NHL) that has been increasing in incidence over the past three decades. Unlike systemic extranodal NHL, the response to therapy for PCNSL patients has been somewhat unsatisfactory. However, methotrexate-based chemotherapy and whole-brain radiotherapy have improved the outcome of patients. Unfortunately, treatment-related neurotoxicity is common, especially in the elderly. Although progress has been made in treating PCNSL, there remains no optimal methotrexate dose or frequency. Treatment of recurrence also remains controversial. These important questions have prompted several clinical studies looking at novel ways to intensify chemotherapy and limit neurotoxicity.

publication date

  • January 1, 2005

Research

keywords

  • Central Nervous System Neoplasms
  • Lymphoma

Identity

Scopus Document Identifier

  • 14044259398

Digital Object Identifier (DOI)

  • 10.1007/s11912-005-0025-x

PubMed ID

  • 15610686

Additional Document Info

volume

  • 7

issue

  • 1