Agminated acquired melanocytic nevi of the common and dysplastic type. uri icon

Overview

abstract

  • We previously reported a single case of agminated acquired melanocytic nevi, consisting of a localized clustering of banal and atypical moles. We now report 4 more cases, confirming that the initial case was not an isolated finding. We examined the lesions clinically, with a dermoscope, with a Wood's light, and in 3 cases with UV photography so as to exclude nevus spilus from the differential diagnosis. The presence of an underlying dysplastic nevus syndrome phenotype in 4 of the 5 cases raises the possibility that agminated nevi arise as a consequence of postzygotic loss of heterozygosity and, thus, may represent a type 2 segmental manifestation of the atypical mole syndrome phenotype. Further studies of similar cases using microdissection techniques for analysis of loss of heterozygosity pattern are warranted.

publication date

  • January 1, 2005

Research

keywords

  • Nevus, Pigmented
  • Skin Neoplasms

Identity

Scopus Document Identifier

  • 11144258893

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2004.05.033

PubMed ID

  • 15627083

Additional Document Info

volume

  • 52

issue

  • 1