Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation. Academic Article uri icon

Overview

abstract

  • To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

publication date

  • January 25, 2005

Research

keywords

  • Corpus Striatum
  • Dystonia Musculorum Deformans
  • Molecular Chaperones
  • Receptors, Dopamine D2

Identity

Scopus Document Identifier

  • 12544260182

Digital Object Identifier (DOI)

  • 10.1212/01.WNL.0000149764.34953.BF

PubMed ID

  • 15668438

Additional Document Info

volume

  • 64

issue

  • 2