ADAMs: key components in EGFR signalling and development. Review uri icon

Overview

abstract

  • ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

publication date

  • January 1, 2005

Research

keywords

  • ErbB Receptors
  • Metalloendopeptidases
  • Signal Transduction

Identity

Scopus Document Identifier

  • 11244261160

Digital Object Identifier (DOI)

  • 10.1038/nrm1548

PubMed ID

  • 15688065

Additional Document Info

volume

  • 6

issue

  • 1