Long-term follow-up of adrenal medullary transplantation for Parkinson's disease. Academic Article uri icon

Overview

abstract

  • Long-term follow-up of eight patients who underwent stereotactic grafting of adrenal medullary tissue into unilateral or bilateral caudate nuclei is presented. We demonstrate that this procedure can be performed with minimal risk. Our results show little benefit when the group as a whole is analyzed. A subgroup of four patients was identified who responded to the procedure, as evidenced by a reduction in motor scores, reduction in medication requirements, and greater "on" time. Three of these patients continue to accrue benefit after 2 years. No characterization of a responder profile was evident. We conclude that a modest benefit is derived from this procedure that may persist for as long as 2 years. Future clinical studies to evaluate grafting procedures are encouraged.

publication date

  • January 1, 1992

Research

keywords

  • Adrenal Medulla
  • Parkinson Disease
  • Postoperative Complications
  • Stereotaxic Techniques

Identity

Scopus Document Identifier

  • 0026596846

Digital Object Identifier (DOI)

  • 10.1177/002383099200500106

PubMed ID

  • 1571072

Additional Document Info

volume

  • 5

issue

  • 1