Organization of vesicular trafficking in epithelia. Review uri icon

Overview

abstract

  • Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.

publication date

  • March 1, 2005

Research

keywords

  • Cytoplasmic Vesicles
  • Epithelium
  • Signal Transduction

Identity

Scopus Document Identifier

  • 14644401811

Digital Object Identifier (DOI)

  • 10.1038/nrm1593

PubMed ID

  • 15738988

Additional Document Info

volume

  • 6

issue

  • 3