Differential diagnosis of cholestasis following allogeneic hematopoietic stem cell transplantation in children: the contribution of serum bile acid levels in relation to other liver function tests. Academic Article uri icon

Overview

abstract

  • Hepatic complications associated with cholestasis occur frequently in hematopoietic stem cell transplant recipients. Since bile acid seems to be a sensitive indicator of beginning cholestasis, the authors monitored total serum bile acid levels in addition to the standard liver function tests in 23 recipients of allogeneic transplants between June 1999 and September 2000. The observations suggest that bile acid is an early and sensitive marker of hepatic GvHD but not as specific as bilirubin. For cholestasis in absence of hepatic GvHD bile acid seems to be more sensitive than bilirubin. Routinely monitoring of bile acid after hematopoietic stem cell transplantation is not indicated.

publication date

  • December 1, 2004

Research

keywords

  • Cholestasis
  • Hematopoietic Stem Cell Transplantation

Identity

Scopus Document Identifier

  • 9644290878

Digital Object Identifier (DOI)

  • 10.1080/08880010490514741

PubMed ID

  • 15739624

Additional Document Info

volume

  • 21

issue

  • 8