Organosilanols as catalysts in asymmetric aryl transfer reactions. Academic Article uri icon

Overview

abstract

  • [reaction: see text] Various ferrocene-based organosilanols have been synthesized in four steps starting from achiral ferrocene carboxylic acid. Applying these novel planar-chiral ferrocenes as catalysts in asymmetric phenyl transfer reactions to substituted benzaldehydes afforded products with high enantiomeric excesses. The best result (91% ee) was achieved in the addition to p-chlorobenzaldehyde with organosilanol 2b, which has a tert-butyl substituent on the oxazoline ring and an isopropyl group on the silanol fragment.

publication date

  • March 31, 2005

Identity

Digital Object Identifier (DOI)

  • 10.1021/ol050242+

PubMed ID

  • 15787518

Additional Document Info

volume

  • 7

issue

  • 7