DNA photocleavage and biological activity of a pyrene dihydrodioxin. Academic Article uri icon

Overview

abstract

  • A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.

publication date

  • April 15, 2005

Research

keywords

  • DNA
  • DNA Damage
  • Dioxins
  • Pyrenes
  • Ultraviolet Rays

Identity

Scopus Document Identifier

  • 15944424661

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2005.02.003

PubMed ID

  • 15808491

Additional Document Info

volume

  • 15

issue

  • 8