Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A. Academic Article uri icon

Overview

abstract

  • T lymphocytes that are activated in the autologous mixed lymphocyte reaction (MLR) have suppressor activity. Concanavalin A (Con A) augments the suppressor activity generated in cultures containing both T and non-T lymphocytes and can induce suppressor activity in T-lymphocyte preparations that contain too few (10%) non-T cells to generate a significant autologous MLR. However, when such T-lymphocyte preparations are further depleted of adherent cells and contain less than 2% non-T cells, Con A fails to induce suppressor activity. These findings support the concept that an autologous MLR may play an important role in generation of suppressor cells by Con A.

publication date

  • December 1, 1979

Research

keywords

  • Antibody Formation
  • Concanavalin A
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • T-Lymphocytes
  • T-Lymphocytes, Regulatory

Identity

PubMed Central ID

  • PMC371314

Scopus Document Identifier

  • 0018612267

Digital Object Identifier (DOI)

  • 10.1172/JCI109622

PubMed ID

  • 159315

Additional Document Info

volume

  • 64

issue

  • 6