Emergence and spread of Streptococcus pneumoniae with erm(B) and mef(A) resistance. Academic Article uri icon

Overview

abstract

  • Streptococcus pneumoniae isolates (N = 31,001) were collected from patients with community-acquired respiratory tract infections during the PROTEKT US surveillance study (2000-2003). While the macrolide (erythromycin) resistance rate remained stable at approximately 29%, the prevalence of resistant isolates containing both erm(B) and mef(A) increased from 9.7% in year 1 to 16.4% in year 3, with substantial regional variability. Almost all (99.2%) dual erm(B) + mef(A) macrolide-resistant isolates exhibited multidrug resistance, whereas 98.6% and 99.0% were levofloxacin- and telithromycin-susceptible, respectively. These strains were most commonly isolated from the ear or middle-ear fluid of children. Of 152 representative erm(B)+mef(A) isolates, >90% were clonally related to the multidrug-resistant international Taiwan19F-14 clonal complex 271 (CC271). Of 366 erm(B)+mef(A) isolates from the PROTEKT global study (1999-2003), 83.3% were CC271, with the highest prevalence seen in South Africa, South Korea, and the United States. This study confirms the increasing global emergence and rapidly increasing US prevalence of this multidrug-resistant pneumococcal clone.

publication date

  • June 1, 2005

Research

keywords

  • Anti-Bacterial Agents
  • Communicable Diseases, Emerging
  • Drug Resistance, Bacterial
  • Macrolides
  • Streptococcus pneumoniae

Identity

PubMed Central ID

  • PMC3367592

Scopus Document Identifier

  • 19344372246

Digital Object Identifier (DOI)

  • 10.1128/IAI.73.1.369-377.2005

PubMed ID

  • 15963279

Additional Document Info

volume

  • 11

issue

  • 6