Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Cell transplantation is safe in animal models and enhances recovery from stroke in rats. METHODS: We studied the safety and feasibility of fetal porcine transplantation in 5 patients with basal ganglia infarcts and stable neurological deficits. To prevent rejection, cells were pretreated with an anti-MHC1 antibody and no immunosuppressive drugs were given to the patients. RESULTS: The first 3 patients had no adverse cell, procedure, or imaging-defined effects. The fourth patient had temporary worsening of motor deficits 3 weeks after transplantation, and the fifth patient developed seizures 1 week after transplantation. MRI in both patients demonstrated areas of enhancement remote from the transplant site, which resolved on subsequent imaging. Two patients showed improvement in speech, language, and/or motor impairments over several months and persisted at 4 years. The study was terminated by the FDA after the inclusion of 5 patients. CONCLUSION: This is the first report on the transplantation of nontumor cells in ischemic stroke patients.

publication date

  • June 21, 2005

Research

keywords

  • Basal Ganglia Cerebrovascular Disease
  • Cell Transplantation
  • Fetal Tissue Transplantation
  • Neurons
  • Transplantation, Heterologous

Identity

Scopus Document Identifier

  • 23844487540

Digital Object Identifier (DOI)

  • 10.1159/000086518

PubMed ID

  • 15976503

Additional Document Info

volume

  • 20

issue

  • 2