Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. Review uri icon

Overview

abstract

  • Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes that are critical to the development of immunity. Investigators have emphasized the role of DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell responses. More recent evidence supports important roles for DCs in the onset of innate immunity and peripheral tolerance. Progress in the generation of DCs from defined hemopoietic precursors in vitro has revealed the heterogeneity of these APCs and their attendant divisions of labor. This review will address these developments in an attempt to integrate the activities of different DCs in coordinating innate and adaptive immunity.

publication date

  • August 1, 2005

Research

keywords

  • Antigen Presentation
  • Dendritic Cells

Identity

Scopus Document Identifier

  • 22544458771

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.175.3.1373

PubMed ID

  • 16034072

Additional Document Info

volume

  • 175

issue

  • 3