The molecular basis of cardiac arrhythmias in patients with cardiomyopathy. Review uri icon

Overview

abstract

  • Cardiac arrhythmias are a leading cause of mortality and morbidity in Western society. In some specific instances, these arrhythmias are caused by abnormalities of cardiac ion channels, such as sodium, calcium, and potassium channels, which carry ionic currents and are fundamental determinants of cardiac excitability. Abnormalities of these ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function of channels, which can predispose to arrhythmias. During heart failure, many channels also malfunction because of altered expression, resulting in lethal arrhythmias.

publication date

  • September 1, 2004

Research

keywords

  • Cardiomyopathy, Dilated
  • Death, Sudden, Cardiac
  • Electrocardiography
  • Tachycardia, Ventricular

Identity

Scopus Document Identifier

  • 23944438481

Digital Object Identifier (DOI)

  • 10.1007/s11897-004-0018-3

PubMed ID

  • 16036032

Additional Document Info

volume

  • 1

issue

  • 3