IL-15: targeting CD8+ T cells for immunotherapy. Review uri icon

Overview

abstract

  • IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8+ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper, we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8+ T cells.

publication date

  • January 1, 2005

Research

keywords

  • CD8-Positive T-Lymphocytes
  • Immunotherapy
  • Interleukin-15
  • Lymphocyte Activation

Identity

Scopus Document Identifier

  • 17444398212

Digital Object Identifier (DOI)

  • 10.1080/14653240510018037

PubMed ID

  • 16040381

Additional Document Info

volume

  • 7

issue

  • 1