Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARgamma partial agonists. Academic Article uri icon

Overview

abstract

  • A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARgamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

publication date

  • November 15, 2005

Research

keywords

  • Indoles
  • PPAR gamma

Identity

Scopus Document Identifier

  • 25844513595

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2005.08.002

PubMed ID

  • 16153845

Additional Document Info

volume

  • 15

issue

  • 22