Neuroimaging of zinc released by depolarization of rat retinal cells. Academic Article uri icon

Overview

abstract

  • Zinc is associated with glutamatergic pathways in brain and retina, yet its role in neuromodulation remains unknown. High concentrations of reactive zinc in vertebrate photoreceptor terminals suggest a neuromodulatory role in the outer plexiform layer but zinc release has not been demonstrated. Using the membrane-impermeable form of the Zn(2+) sensitive fluorescent dye Newport Green, we have demonstrated increased release of Zn(2+) from the rat retina in response to potassium-induced depolarization of retinal cells. This increase was greatest in the outer retina with densest bands observed in the outer plexiform layer and photoreceptor inner segment regions of rat retinal slices.

publication date

  • September 21, 2005

Research

keywords

  • Retina
  • Zinc

Identity

Scopus Document Identifier

  • 28444432986

Digital Object Identifier (DOI)

  • 10.1016/j.visres.2005.07.039

PubMed ID

  • 16181655

Additional Document Info

volume

  • 45

issue

  • 28