Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: We investigated whether levels of annexin A5, evidence for resistance to annexin A5 activity, and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses. STUDY DESIGN: These annexin A5 parameters were assayed in 70 nonpregnant women with a history of > or = 3 recurrent spontaneous pregnancy losses (cases) and 50 women without adverse pregnancy history (control subjects). RESULTS: Cases had significantly lower plasma annexin A5 levels than control subjects (median, 4.7 ng/mL [range, 0.3-40.4 ng/mL] vs 6.7 ng/mL [range, 0.7-56.0]; P = .01), significantly reduced anticoagulant ratios (188% [range, 119%-279%] vs 238% [range, 159%-286%]; P < .0001), and reduced binding of annexin A5 to phospholipid (6.3 ng/aliquot phospholipid [range, 1.5-16.4 ng/aliquot phospholipid] vs 9.7 ng/aliquot phospholipid (range, 3.5-17.0 ng/aliquot phospholipid]; P = .0002). There were no significant differences in anti-annexin A5 antibody levels. CONCLUSION: Reduction of annexin A5 and interference with its anticoagulant and binding activities are associated significantly with a history of recurrent spontaneous pregnancy losses. These data support the concept of a significant role for annexin A5 in the maintenance of pregnancy.

authors

  • Rand, Jacob H.
  • Arslan, Alan A
  • Wu, Xiao-Xuan
  • Wein, Rosemary
  • Mulholland, Jeanine
  • Shah, Manish
  • van Heerde, Waander L
  • Reutelingsperger, Chris P
  • Lockwood, Charles J
  • Kuczynski, Edward

publication date

  • January 1, 2006

Research

keywords

  • Abortion, Habitual
  • Annexin A5
  • Antibodies
  • Anticoagulants

Identity

Scopus Document Identifier

  • 29544437912

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2005.05.034

PubMed ID

  • 16389029

Additional Document Info

volume

  • 194

issue

  • 1