Identification of prognostic factors after positive second-look surgery in epithelial ovarian carcinoma. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: The objective of this study was to identify independent prognostic factors for survival in patients with epithelial ovarian cancer who had persistent disease identified at second-look surgery. METHODS: We performed a retrospective chart review of all patients with epithelial ovarian cancer who had positive findings at second-look surgery between June 1991 and June 2002. All patients achieved a complete clinical remission after a prescribed course of primary therapy. Survival was determined from the time of second-look surgery until last follow-up or death. RESULTS: The study included a total of 262 patients, with a median age of 54 years (range, 22-80). Of the 262 patients, 166 (63%) had died of disease. Records of initial (salvage) treatment after the positive second-look surgery were available for 243 patients. Therapies included the following: intraperitoneal (IP) cisplatin, 71 (29%); IP cisplatin combined with a second drug, 53 (22%); IP therapy other than cisplatin, 29 (12%); intravenous (IV) chemotherapy, 50 (21%); IP and IV therapy, 35 (14%); and oral chemotherapy, 5 (2%). Of the 13 potential prognostic factors analyzed, only 2 factors emerged that, when combined, were significant--residual disease after primary surgery and size of persistent disease found at second-look surgery. Patients with

publication date

  • January 20, 2006

Research

keywords

  • Antineoplastic Agents
  • Ovarian Neoplasms
  • Salvage Therapy

Identity

Scopus Document Identifier

  • 33744911968

Digital Object Identifier (DOI)

  • 10.1016/j.ygyno.2005.11.040

PubMed ID

  • 16427689

Additional Document Info

volume

  • 102

issue

  • 1