IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle. Academic Article uri icon

Overview

abstract

  • Amyotrophic lateral sclerosis (ALS) is a devastating human disease of upper and lower motoneurons. We studied the action of the immunoglobulin G (IgG) from ALS and disease control patients on dihydropyridine (DHP)-sensitive Ca2+ channels in single mammalian skeletal muscle fibers with the double Vaseline gap technique. The peak of the Ca2+ current (ICa) and the charge movement were reduced when the fibers were incubated in ALS IgG. These effects were lost when the IgG was boiled or adsorbed with skeletal tubular membranes. ALS IgG reduced skeletal muscle ICa in a similar fashion as nifedipine; the ICa blockade was voltage dependent, and the associated charge movement was reduced. These observations suggest that IgG from ALS patients reacts with the skeletal muscle DHP-sensitive Ca2+ channels or some associated regulatory moiety.

publication date

  • June 1, 1991

Research

keywords

  • Amyotrophic Lateral Sclerosis
  • Calcium Channels
  • Immunoglobulin G

Identity

Scopus Document Identifier

  • 0025781860

Digital Object Identifier (DOI)

  • 10.1152/ajpcell.1991.260.6.C1347

PubMed ID

  • 1647668

Additional Document Info

volume

  • 260

issue

  • 6 Pt 1