MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. Academic Article uri icon

Overview

abstract

  • The MyD88 adaptor protein is critical in Toll-like receptor and interleukin 1 receptor (IL-1R) signaling, but has not been linked to interferon-gamma receptor (IFN-gammaR) signaling. Here we demonstrate that MyD88 increased the half-life but not the synthesis of IFN-gamma-induced mRNA transcripts encoding tumor necrosis factor and IFN-gamma-inducible protein 10. IFN-gamma stimulation triggered a physical association between the IFN-gammaR1 and MyD88. Transcript stabilization required activation of mixed-lineage kinase 3 and p38 mitogen-activated protein kinase and the presence of an adenine-uridine-rich element in the transcript's 3' untranslated region. These results demonstrate a MyD88-dependent post-transcriptional mechanism through which IFN-gamma can enhance the expression of genes encoding proinflammatory molecules.

publication date

  • February 19, 2006

Research

keywords

  • Adaptor Proteins, Signal Transducing
  • Chemokines, CXC
  • Interferon-gamma
  • Tumor Necrosis Factor-alpha

Identity

Scopus Document Identifier

  • 33645101274

Digital Object Identifier (DOI)

  • 10.1038/ni1308

PubMed ID

  • 16491077

Additional Document Info

volume

  • 7

issue

  • 4