Annexin A5 levels in midtrimester amniotic fluid: association with intrauterine growth restriction. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: The purpose of this study was to determine whether amniotic fluid levels of annexin A5 (AF-AnxA5) may be associated with intrauterine growth restriction (IUGR). STUDY DESIGN: Amniotic fluid was obtained in a cohort of pregnant patients (n = 172) undergoing amniocentesis at 15 to 24 weeks' gestation and annexin A5 (AnxA5) levels were determined with enzyme-linked immunosorbent assay (ELISA). Patients who developed IUGR were compared with the remainder of the cohort. RESULTS: AF-AnxA5 levels significantly increased through gestation (P = .003). The mean level of AF-AnxA5 in IUGR patients (n = 15) was significantly higher (P = .028) than in the remainder of the cohort (n = 130). Elevated AF-AnxA5 > 20 ng/mL was associated with a relative risk of 3.5 for the development of IUGR (P = .023). CONCLUSION: AnxA5 is present in amniotic fluid and increases through gestation from 15 to 24 weeks. Elevated AF-AnxA5 levels were present in patients who developed IUGR. AF-AnxA5 may be a useful marker for identifying pregnancy abnormalities.

publication date

  • March 30, 2006

Research

keywords

  • Amniotic Fluid
  • Annexin A5
  • Fetal Growth Retardation
  • Pregnancy Trimester, Second

Identity

Scopus Document Identifier

  • 33646088960

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2005.11.005

PubMed ID

  • 16579937

Additional Document Info

volume

  • 194

issue

  • 5