Catalytic asymmetric approaches towards enantiomerically enriched diarylmethanols and diarylmethylamines. Review uri icon

Overview

abstract

  • Enantiopure diarylmethanols and diarylmethylamines are important intermediates for the synthesis of pharmaceutically relevant products with antihistaminic, antiarrhythmic, diuretic, antidepressive, laxative, local-anesthetic and anticholinergic properties. Furthermore, they have been used as precursors for 1,1-diarylalkyl moieties, which occur in other antidepressants as well as in antimuscarinics and endothelin antagonists. In this critical review catalytic strategies towards enantioenriched diarylmethanols and diarylmethylamines are discussed, including methods for asymmetric carbon-carbon bond formations by aryl transfer reactions to aldehydes and arylimines, respectively, and enantioselective reductions of diarylketones.

publication date

  • March 16, 2006

Research

keywords

  • Methanol
  • Methylamines

Identity

Scopus Document Identifier

  • 33745760081

Digital Object Identifier (DOI)

  • 10.1039/b600091f

PubMed ID

  • 16636728

Additional Document Info

volume

  • 35

issue

  • 5