Hepatocellular carcinoma in the cirrhotic liver: gadolinium-enhanced 3D T1-weighted MR imaging as a stand-alone sequence for diagnosis. Academic Article uri icon

Overview

abstract

  • PURPOSE: To retrospectively assess the usefulness of contrast material-enhanced T1-weighted magnetic resonance (MR) imaging alone and with T2-weighted MR imaging in the diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A waiver of informed consent and institutional review board approval for this retrospective study were granted. The study was HIPAA compliant. Twenty-eight men (mean age, 49 years; range, 23-70 years) and 10 women (mean age, 53 years; range, 42-72 years) with cirrhosis underwent T2-weighted and contrast-enhanced T1-weighted MR imaging at 1.5 T within 90 days of liver transplantation. Three readers reviewed the T1-weighted images alone and then the T2-weighted and T1-weighted images together. Lesion detection, characterization, and reader confidence levels were recorded. RESULTS: At liver explantation, 57 lesions were present in 18 patients: 19 HCCs, 33 dysplastic nodules, and five cysts. Contrast-enhanced T1-weighted imaging depicted 13 of 19 HCCs with an overall sensitivity of 68.4% (13 of 19) and specificity of 65.7% (23 of 35). The sensitivity and specificity for detection of dysplastic nodules (sensitivity, 9%; specificity, 68.4%) and HCCs (sensitivity, 68.4%; specificity, 65.7%) were nearly identical for T1-weighted images read alone or read with T2-weighted images. The only difference was the specificity for T1-weighted images read alone (65.7%) and read with T2-weighted images (62.9%). The addition of T2-weighted images altered the diagnosis in one of 90 (1.1%) cases and provided an increase in diagnostic confidence in four of 258 (1.6%) cases for independent readers and three of 90 (3.3%) cases at consensus reading. CONCLUSION: Contrast-enhanced T1-weighted imaging can be used as a stand-alone sequence for the diagnosis of HCC in patients with cirrhosis prior to liver transplantation.

authors

  • Hecht, Elizabeth
  • Holland, Agnes E
  • Israel, Gary M
  • Hahn, Winnie Y
  • Kim, Danny C
  • West, A Brian
  • Babb, James S
  • Taouli, Bachir
  • Lee, Vivian S
  • Krinsky, Glenn A

publication date

  • May 1, 2006

Research

keywords

  • Carcinoma, Hepatocellular
  • Contrast Media
  • Gadolinium DTPA
  • Imaging, Three-Dimensional
  • Liver Cirrhosis
  • Liver Neoplasms
  • Magnetic Resonance Imaging

Identity

Scopus Document Identifier

  • 33646155738

Digital Object Identifier (DOI)

  • 10.1148/radiol.2392050551

PubMed ID

  • 16641353

Additional Document Info

volume

  • 239

issue

  • 2