Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. Academic Article uri icon

Overview

abstract

  • The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such changes to the neoplastic phenotype. To further our understanding of the genetic basis of human squamous cell carcinoma (SCC) of the skin, this study used a genome-wide (12 627 sequences) approach to determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving the p53 pathway, anti-apoptotic pathways, signal transduction, structural loss and DNA replication, including BCL2A1, MUC4, PTPN11 (SHP2) and FGF9, are upregulated in SCC and could warrant further study regarding their role in disease pathogenesis. SCC pathology is likely combinatorial in nature involving the compounded changes from several cellular processes.

publication date

  • May 1, 2006

Research

keywords

  • Carcinoma, Squamous Cell
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Skin Neoplasms

Identity

Scopus Document Identifier

  • 33745312176

Digital Object Identifier (DOI)

  • 10.1111/j.1346-8138.2006.00075.x

PubMed ID

  • 16700662

Additional Document Info

volume

  • 33

issue

  • 5