Chemotherapy for non-clear-cell renal cell carcinoma. Review uri icon

Overview

abstract

  • Clear-cell carcinoma is the most common histopathologic subtype of kidney tumors. Consequently, clinical trials for advanced-stage kidney cancer have focused on patients with clear-cell carcinoma and not on the less common subtypes, including papillary, chromophobe, collecting-duct carcinoma, and sarcomatoid-variant tumors. Whereas immunotherapy has constituted the standard treatment for patients with clear-cell renal cell carcinoma (RCC), it does not appear to have activity in the management of patients with other histologic subtypes. Novel therapies, including those targeting the vascular endothelial growth factor pathway, have recently demonstrated significant activity in clear-cell RCC. Historically, chemotherapy has shown limited activity in advanced-stage RCC; however, clinical trials to date have failed to individualize treatment based on histologic subtype. In this article, we will review the literature and present our experience with the use of chemotherapy in patients with non-clear-cell kidney cancer by histologic subtype.

publication date

  • March 1, 2006

Research

keywords

  • Antineoplastic Agents
  • Carcinoma, Renal Cell
  • Kidney Neoplasms

Identity

Scopus Document Identifier

  • 33646873759

Digital Object Identifier (DOI)

  • 10.3816/CGC.2006.n.005

PubMed ID

  • 16729909

Additional Document Info

volume

  • 4

issue

  • 4