Increasing external beam dose for T1-T2 prostate cancer: effect on risk groups. Academic Article uri icon

Overview

abstract

  • PURPOSE: The aim of this study was to investigate effect of increasing dose on risk groups for clinical failure (CF: local failure or distant failure or hormone ablation or PSA>or=25 ng/ml) in patients with T1-T2 prostate cancer treated with external beam radiotherapy. METHODS AND MATERIALS: Patients (n=4,537) were partitioned into nonoverlapping dose ranges, each narrow enough that dose was not a predictor of CF, and risk groups for CF were determined using recursive partitioning analysis (RPA). The same technique was applied to the highest of these dose ranges (70-76 Gy, 1,136 patients) to compare risk groups for CF in this dose range with the conventional risk-group classification. RESULTS: Cutpoints defining low-risk groups in each dose range shifted to higher initial PSA levels and Gleason scores with increasing dose. Risk groups for CF in the dose range 70-76 Gy were not consistent with conventional risk groups. CONCLUSIONS: The conventional classification of risk groups was derived in the early PSA era, when total doses<70 Gy were common, and it is inconsistent with risk groups for patients treated to doses>70 Gy. Risk-group classifications must be continuously re-examined whenever the trend is toward increasing total dose.

publication date

  • June 5, 2006

Research

keywords

  • Prostatic Neoplasms
  • Radiotherapy Dosage

Identity

Scopus Document Identifier

  • 33745192826

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2006.02.043

PubMed ID

  • 16750319

Additional Document Info

volume

  • 65

issue

  • 4