Motor cortex reorganisation in Parkinson's disease. Academic Article uri icon

Overview

abstract

  • Transcranial magnetic stimulation mapping of the motor cortical projection to the hand was performed in a group of patients with Parkinson's disease (PD) of variable duration to determine whether there is evidence of cortical reorganisation. Map shifts were found in the majority of PD cases (12/15), in untreated early cases as well as treated cases of longer duration, and there was a correlation between inter-side difference in the severity of PD symptoms (Unified Parkinson's Disease Rating Scale) and interhemispheric map displacement (r=0.60; P=0.018). These findings indicate that there is reorganisation of the corticomotor representation of the hand in PD, even at a relatively early stage of the disease, and suggest a dynamic process of reorganisation in the motor cortex due to an increase in the pallidal inhibitory inputs to the thalamo-cortical projections.

publication date

  • June 30, 2006

Research

keywords

  • Motor Cortex
  • Parkinson Disease

Identity

Scopus Document Identifier

  • 33746030659

Digital Object Identifier (DOI)

  • 10.1016/j.jocn.2005.06.013

PubMed ID

  • 16814549

Additional Document Info

volume

  • 13

issue

  • 6