Predictors of embryo fragmentation and outcome after fragment removal in in vitro fertilization. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To assess predictors of embryo fragmentation in IVF as well as to compare cycle outcomes between low-grade embryos subjected to defragmentation and high-grade embryos not undergoing defragmentation. DESIGN: A retrospective, case-control trial. SETTING: A university hospital IVF program. PATIENT(S): Three hundred twenty-seven nondonor, fresh IVF cycles. MAIN OUTCOME MEASURE(S): Predictors of fragmentation. We evaluated age, basal FSH and E(2) levels, the number of retrieved oocytes, and fertilization rates. Outcome assessments following defragmentation included rates of implantation, clinical pregnancy, spontaneous abortion, and live birth. RESULT(S): Increased age and lower number of oocytes and embryos were associated with embryo fragmentation. Lower-grade embryos after defragmentation yielded rates of implantation, clinical pregnancy, live birth, spontaneous abortion, and fetal defects equivalent to high-grade embryos. CONCLUSION(S): Fragmented embryos correlate with poorer prognosis cycles; however, fragmented embryos that undergo defragmentation result in equivalent clinical outcomes to high-grade, nondefragmented embryos.

publication date

  • July 5, 2006

Research

keywords

  • Cleavage Stage, Ovum
  • Fertilization in Vitro

Identity

Scopus Document Identifier

  • 33746345349

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2006.01.048

PubMed ID

  • 16824522

Additional Document Info

volume

  • 86

issue

  • 2