Social stress-related behavior affects hippocampal cell proliferation in mice. Academic Article uri icon

Overview

abstract

  • Although social stress inhibits neurogenesis in the adult hippocampus, the extent to which individual differences in stress-related behavior affect hippocampal cell proliferation is not well understood. Based on results from resident-intruder stress tests administered to adult male mice, here we report that individual differences in hippocampal cell proliferation are related to the frequency of defensive behavior, and not the amount of aggression received or the frequency of fleeing. In contrast, access to voluntary wheel-running exercise did not affect hippocampal cell proliferation in either stressed or non-stressed mice. Social stress-induced inhibition of cell proliferation was restricted to the hippocampus, as neither stress nor access to wheel-running exercise altered cell proliferation in the amygdala. These findings indicate that individual differences in stress-related behavior influence cell proliferation in the mouse hippocampus, and may have important implications for understanding structural and functional hippocampal impairments in human psychiatric patients.

publication date

  • July 11, 2006

Research

keywords

  • Behavior, Animal
  • Cell Proliferation
  • Hippocampus
  • Neurons
  • Social Environment
  • Stress, Psychological

Identity

Scopus Document Identifier

  • 33747355417

Digital Object Identifier (DOI)

  • 10.1016/j.physbeh.2006.05.047

PubMed ID

  • 16837015

Additional Document Info

volume

  • 89

issue

  • 2