Effects of CCK-8 on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days 10 and 11. Academic Article uri icon

Overview

abstract

  • Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 microg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 microg/kg did, but was more potent than 5 microg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 microg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.

publication date

  • July 24, 2006

Research

keywords

  • Eating
  • Prosencephalon
  • Proto-Oncogene Proteins c-fos
  • Rhombencephalon
  • Sincalide

Identity

Scopus Document Identifier

  • 33751012413

Digital Object Identifier (DOI)

  • 10.1016/j.peptides.2006.05.024

PubMed ID

  • 16860903

Additional Document Info

volume

  • 27

issue

  • 11