Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: experimental autoimmune gray matter disease. Academic Article uri icon

Overview

abstract

  • Guinea pigs immunized with bovine spinal cord ventral horn homogenate develop muscle weakness with electromyographic and morphologic evidence of denervation. Pathological examination demonstrates a loss of motoneurons and scattered inflammatory foci primarily localized to the spinal cord. Immunohistochemical techniques document the presence of immunoglobulin G at the motor end plate and around the external membrane and within the cytoplasm of motoneurons. This syndrome of experimental autoimmune gray matter disease (EAGMD) differs from experimental autoimmune motor neuron disease induced by inoculation with purified motoneurons and also differs from experimental autoimmune encephalomyelitis. The existence of two different forms of immune-mediated motoneuron destruction suggests that a number of cytoplasmic and membrane antigens may give rise to an immunologically based attack on the motor system.

publication date

  • April 1, 1990

Research

keywords

  • Autoimmune Diseases
  • Immunization
  • Motor Neurons
  • Periaqueductal Gray
  • Spinal Cord

Identity

Scopus Document Identifier

  • 0025319048

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(90)90132-7

PubMed ID

  • 1690752

Additional Document Info

volume

  • 27

issue

  • 1